The Oprah Winfrey show along with the Oprah book club is singing the praises of Jeffrey Eugenides' new book "Middlesex". This is the story of a gene that passes down through three generations of a Greek-American family. The story focuses on how it effects the body of Calliope Stephanides. This Oprah Book Club classic begins: "I was born twice: first, as a baby girl, on a remarkably smog less Detroit day in January of 1960; and then again, as a teenage boy, in an emergency room near Petoskey, Michigan, in August of 1974." The Oprah magazine hails this novel as traces the story of his transformation and the genetic condition that created it back to his paternal grandparents, who happen also to be brother and sister, and the Greek village of Bithynios in Asia Minor. This Oprah book club masterpiece, Middlesex, is a story about what it means to occupy the confused and scary middle ground between male and female, Greek and American, past and present. Jeffrey Eugenides's epic portrayal of struggle is classical in its structure and scope and contemporary in its content—a tender and honest examination of a battle that is increasingly relevant to us all. Once you begin this novel you will see what the Oprah Magazine and The Oprah Winfrey show are talking about.